Reactome_signaling_by_erbb4

Author: dszd

August undefined, 2024

WebBioModels Database:BIOMD0000000468 Show undefined attributes created [InstanceEdit:12173320] Wright, Adam, 2024-03-15 databaseName WebFeb 23, 2024 · Treatment of activated pro-inflammatory macrophages with the ErbB4 ligand neuregulin-4 (NRG4) induced apoptosis. ErbB4 localized to the mitochondria in these cells. Apoptosis was accompanied by loss of mitochondrial membrane potential, and was dependent upon the proteases that generate the cleaved ErbB4 intracellular domain …

Entry - *600543 - ERB-B2 RECEPTOR TYROSINE KINASE 4; ERBB4

WebApr 14, 2024 · Impaired ErbB4 signaling in the hypothalamus of HFD-fed mice. A,B) Metabolic tissue-specific expression levels of Nrg4 and ErbB4 were measured in lean C57BL/6J male mice and are presented as ΔCT values (n = 3 for each group).C) tdTomato of ErbB4-CreER::Ai14 mice showing ErbB4 expression in the PVN, DMH, VMH, and Arc of the … WebJun 12, 2024 · The results indicate that ERBB4 is a unique coregulator of ER, directly coupling extranuclear and nuclear estrogen actions in breast cancer and proposes that the contribution of an autocrine ER BB4/ER signaling pathway to tumor growth and therapeutic response should be considered when managing patients with ER-positive breast cancer. … i own too much stuff

Applied Sciences Free Full-Text ErbB4 Is a Potential Key …

WebNuclear signaling by ERBB4 Pathway - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 403 Forbidden National … WebLog-likelihood per target Total log-likelihood Term Description; 0.3: 3.3: REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE: Genes involved in Translocation of ZAP-70 to WebApr 14, 2024 · Impaired ErbB4 signaling in the hypothalamus of HFD-fed mice. A,B) Metabolic tissue-specific expression levels of Nrg4 and ErbB4 were measured in lean … i own this website now

ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis …

REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS

WebAt least three and possibly four splicing isoforms of ERBB4 exist that differ in their C-tail and/or the extracellular juxtamembrane regions: ERBB4 JM-A CYT1, ERBB4 JM-A CYT2 and ERBB4 JM-B CYT1 (the existence of ERBB4 JM-B CYT2 has not been confirmed). The longest variant of each gene is displayed. WebFeb 28, 2024 · We found that genes regulating the expression of the upregulated genes (i.e., upstream regulators) were enriched in the “signaling by ERBB4 ” pathway. ERBB4 was also one of three genes encoding master regulators whose expression was increased only in samples with an NTRK fusion. Moreover, the algorithm searching for positive feedback … iown washingtonWebREACTOME_SIGNALING_BY_ERBB4: Systematic name: M544: Brief description: Signaling by ERBB4: Full description or abstract : Collection: C2: Curated CP: Canonical Pathways … opening relations with china quizlet

"WebNuclear signaling by ERBB4. Besides signaling as a transmembrane receptor, ligand activated homodimers of ERBB4 JM-A isoforms (ERBB4 JM-A CYT1 and ERBB4 JM-A … " - Reactome_signaling_by_erbb4

Reactome_signaling_by_erbb4

WebJun 12, 2024 · The ErbB-4 receptor protein-tyrosine kinase is proteolytically processed by membrane proteases in response to the ligand or 12-O-tetradecanoylphorbol-13-acetate … WebMar 19, 2024 · ErbB4 signaling modulates proliferation and polarization, cellular functions critical for the development of epithelial ducts in the kidney. The ErbB4 signaling maintains high efficacy of synaptic transmission by stabilizing the postsynaptic apparatus via phosphorylation of alpha-dystrobrevin1.

Did you know?

Webreactome_nuclear_signaling_by_erbb4 reactome_nucleotide_binding_domain_ leucine_rich_repeat_containing_rece ptor_nlr_signaling_pathways … WebThe ErbB receptors signal through Akt, MAPK, and many other pathways to regulate cell proliferation, migration, differentiation, apoptosis, and cell motility. ErbB family members and some of their ligands are often over-expressed, amplified, or mutated in many forms of cancer, making them important therapeutic targets.

WebNov 3, 2015 · The epidermal growth factor receptor (EGFR) family member ERBB4, which forms signaling complexes with other EGFR family members, can undergo ligand-induced proteolytic cleavage to release a soluble intracellular domain (ICD) that enters the nucleus to modify transcription.

WebJan 17, 2024 · Nuclear signaling by ERBB4. This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at … WebCompendia expression profiles ?: GTEx compendium Human tissue compendium (Novartis) Global Cancer Map (Broad Institute) NCI-60 cell lines (National Cancer Institute): Advanced query: Further investigate these 297 genes : Gene families ?: Categorize these 297 genes by gene family : Show members (show 321 source identifiers mapped to 297 genes)

WebJan 17, 2024 · Signaling by ERBB4. This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at …

WebERBB4 is a single-pass type I transmembrane protein with multiple furin -like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins -2, -3 and -4, heparin-binding EGF-like growth factor and betacellulin. i own too many fleece jacketsWebHomo sapiens (human) Signaling by ERBB4 (provided by Reactome) Overview Navs Quote/Order Request Now Overview ... About the Signaling by ERBB4 pathway. ERBB4, … opening released back to frontWebREACTOME_CONSTITUTIVE_SIGNALING_BY_OVEREXPRESSED_ERBB2: Systematic name: M29814: Brief description: Constitutive Signaling by Overexpressed ERBB2: Full description or abstract : Collection: C2: Curated CP: Canonical Pathways CP:REACTOME: Reactome Pathways: Source publication : Exact source: R-HSA-9634285: Related gene sets opening refrigerator from the insideWebERBB4 Signaling Pathway (Concept Id: C2984396) The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:jc, PMID:16460914, Reactome:R-HSA-1236394] ERBB4 Signaling Pathway MedGen UID: i own two homes how do i do my taxesWebSignaling by ERBB4 Pathway - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 403 Forbidden National Center for … iown wovenWebERBB4 Signaling Pathway (Concept Id: C2984396) The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell, and … i own too many clothesWebFeb 28, 2024 · We found that genes regulating the expression of the upregulated genes (i.e., upstream regulators) were enriched in the “signaling by ERBB4” pathway. ERBB4 was also one of three genes... i own you hercules