Ews atf1

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August undefined, 2024

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SU-CCS-1 - CRL-2971 ATCC

To establish iPSCs, we introduced OCT3/4, SOX2, KLF4 and cMYC into a murine CCS cell line (G1297) containing doxycycline (Dox)-controllable EWS/ATF1 alleles9. iPSC-like colonies were picked up to establish iPSC-like cell lines (Fig. 1a). The established iPSC-like clones showed elevated activity of alkaline phosphatase … See more We next examined secondary sarcoma development11,12 in sarcoma-iPSC chimeric mice by inducing EWS/ATF1. For control experiments, chimeric mice were generated with embryonic stem cells (ESCs) and iPSCs, … See more Immunohistochemical analysis revealed that EWS/ATF1 is expressed in various organs and tissues of sarcoma-iPSC mice after Dox treatment (day 5, Supplementary Fig. 3a). Notably, … See more It has been reported that human CCSs harbor shared properties with malignant melanomas6. Consistently, previous studies demonstrated a similarity in the global gene … See more Taking advantage of the one-step and cell-type-specific nature of secondary sarcoma development in sarcoma-iPSC mice, we next attempted to … See more WebBecause the EWS-ATF1 fusion transcript and the associated t (12;22) (q13;q12) translocation occur in CCS but not cutaneous melanoma, we investigated the use of … toyah slave chart

ATF1 - ATF1 - abcdef.wiki

WebLatest F1 news in a live feed, including breaking news, race results, driver interviews, analysis, commentary and all updates relating to Formula 1 racing. F1 is an international … WebFeb 28, 2014 · The EWS/ATF1 fusion protein in soft tissue clear cell sarcoma is composed of the EAD (residues 1–325), fused to the C-terminal region of ATF1 (residues 66–271). EWS/ATF1 is a potent constitutive activator of the ATF-dependent promoters, dependent on the EAD and the bZIP domain (AA 214–271), consisting of a basic region that directly ... WebCharles Leclerc Urges Fans To Stay Away From His Home After ‘Crossed Boundaries’ toyah should i stay or should i go

Establishment of a novel clear cell sarcoma cell line (Hewga-CCS), …

The EWS/ATF1 fusion protein contains a dispersed …

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"WebJan 21, 2024 · The EWS/ATF1 fusion gene has also been detected using fluorescence in-situ hybridization (FISH) in bone CCS samples [10, 11, 15]. In contrast, there are no reports confirming whether the EWS/ATF1 or EWSR1/CREB1 fusion genes can be detected using direct sequencing. " - Ews atf1

Ews atf1

WebThe EWSR1/ATF1 fusion gene is involved in a rare type of cancer called soft tissue clear cell sarcoma (or malignant melanoma of soft parts). In this type of cancer, tumors usually … WebOf the 12 cases positive for a split EWSR1 signal, 6 showed rearrangement of ATF1 (50%) (Fig. 7B), 3 showed rearrangement of CREB1 (25%), 2 showed no rearrangements of either ATF1 or CREB1 genes, and in 1 case ATF1 and CREB1 were not evaluated (case 16). One case showed no involvement of EWSR1, ATF1, or CREB1 by FISH

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WebClear cell sarcoma (CCS) is associated with the EWS/ATF1 oncogene that is created by aberrant t(12;22)(q13;q12) chromosomal fusion of the Ewings Sarcoma oncogene (EWS) and the cellular transcription factor ATF1. SU-CCS-1 cell line has been revealed to express the EWS/ATF1 fusion protein, and been used as a valuable tool to study CCS biology … WebAug 14, 2008 · RT-PCR analysis detected an EWS/ATF1 fusion gene between exons 7 and 5, respectively, that functioned as a constitutive transcriptional activator. In a tumor tissue sample from 1 of 9 patients with angiomatoid fibrous histiocytoma, Antonescu et al. (2007) identified an EWS/ATF1 fusion gene, linking exon 7 of EWS to exon 5 of ATF1.

WebCyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene. This gene encodes an activating transcription factor, which belongs to … WebEWS-ATF1, FUS/ATF-1, TREB36. Species: Human ATF1 (466), Mouse Atf1 (11908), Rat Atf1 (315305), Zebrafish... Summary: This gene encodes an activating transcription factor, which belongs to...Show More. Related Products: Antibodies Proteins shRNA Panels esiRNA shRNA siRNA. See All Related Genes.

WebJun 26, 2009 · Molecular diagnosis of clear cell sarcoma: detection of EWS-ATF1 and MITF-M transcripts and histopathological and ultrastructural analysis of 12 cases. J Mol Diagn 2002; 4 :44–52. WebEWS/ATF1 fusion ( 287C) containing the intact EAD (residues 1–287) and the region of ATF1(residues 66–271) present in oncogenic EWS/ATF1. DHRs (light gray boxes) and other non-DHR tyrosines (dark gray) are shown. Tyr to Ala changes (DA, OA, CA, N3OA, and NA) are indicated by green boxes. Gln to Ala changes

WebApr 1, 2024 · Although it has been shown that the EWS/ATF 1 fusion gene is a driver oncogene in CCS ( Straessl er et al., 2013 ; Yamada et al., 2013 ), the downstream effector pathways of EWS/ATF1

WebEWS Is Part of a Family of Genes Frequently Rearranged in Sarcoma and Leukemia and Predisposing to Familial Amyotrophic Lateral Sclerosis. ... At least four major EWSR1/ATF1 splicing variants have been described (Figure 26-5). Type 1 is the most common and results in fusion of EWSR1 exon 8 to ATF1 exon 4 ... toyah steve hoffmanWebSep 5, 2024 · EWS/ATF1 expression induces oncogene-induced senescence in most cell types in sarcoma-iPSC mice but prevents it in sarcoma cells. We identify Tppp3 … toyah sneakers in white leatherWebDr Shyam Reddy discovered and cloned several oncogenes (close to 20 genes) and studied their functions. The most notable genes discovered by Dr Reddy include ERG-1, ERG-2, … toyah street creatureWebGBI investigating officer-involved shooting after Atlanta man jumps out of truck, attacking officer. April 08, 2024 at 12:45 pm EDT. Video. toyah sunday lunch sweet dreamsWebAt least four major EWSR1/ATF1 splicing variants have been described ( Figure 26-5 ). Type 1 is the most common and results in fusion of EWSR1 exon 8 to ATF1 exon 4 … toyah stiletto heeled bootWebAug 18, 2008 · The FUS gene at 16p11.2 was found to be combined with the ATF1 gene at 12q13, generating a chimeric FUS/ATF1. Waters et al. (2000) found that FUS was interrupted at codon 175 and fused to codon 110 of ATF1, resulting in an in-frame junction with a glycine-to-valine (GGT-to-GTT) transition. EWS/ATF1 Fusion Gene toyah texas earthquakeWebNov 1, 2002 · The EWS/ATF1 fusion transcript is detectable in up to 90% of the clear cell sarcoma cases. As described in other EWS rearrangements, the transcript fuses 5 EWS to 3 heterologous sequences. The reciprocal ATF1/EWS fusion probably does not contribute to malignant transformation since it is out of frame. toyah sweet dreams