Cisdiamminedichloroplatinum

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August undefined, 2024

WebJun 1, 1973 · cis -Diamminedichloroplatinum (II) is the first of a group of platinum coordination complexes with antineoplastic activity to be studied in humans. This Phase I investigation characterizes the toxicity and pharmacological disposition of … WebSep 1, 1990 · The specific drug combination and experimental growth system for this introductory application was that of 1-β- d -arabinofuranosylcytosine (ara-C) and cisplatin with simultaneous drug exposure (1, 3, 6, 12, or 48 h) against L1210 leukemia in vitro.

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Webcis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells Pharmacol Ther. 1984;25(3):297-326.doi: 10.1016/0163 … Webcis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells Pharmacol Ther. 1984;25(3):297-326.doi: 10.1016/0163-7258(84)90003-2. Author E B Douple PMID: 6542679 DOI: 10.1016/0163-7258(84)90003-2 No abstract available Publication types tsh slide switch

Possible involvement of thioredoxin reductase as well as …

WebThree Co(III) complexes of a designed ligand PMAH that mimics the metal-binding domain of the antitumor antibiotic bleomycin (BLM) have been isolated and structurally characterized. The coordination WebJan 29, 1985 · Salmon sperm DNA, treated with the antitumor agent cis-diamminedichloroplatinum(II) (cis-DDP), was enzymatically degraded to … WebShort-term cis-diamminedichloroplatinum(II) accumulation in sensitive and resistant human ovarian carcinoma cells We examined the short-term accumulation of cisplatin (DDP) in sensitive 2008 human ovarian carcinoma cells and in a 2- to 3-fold DDP-resistant and accumulation-deficient variant. phil\u0026teds s4 inline stroller with doubles kit

Analysis of resistance-associated gene expression in docetaxel ...

Cis-diamminedichloroplatinum, vinblastine, and bleomycin …

WebAbstract Cis-diamminedichloroplatinum (DDP) was used as the initial treatment in a pilot study of 17 patients with biopsy-proven transitional cell carcinoma of the bladder. No … WebApr 19, 2024 · A platinum-based chemotherapeutic agent, Cisplatin (CDDP), has been widely used to treat many human cancer including cervical cancer, metastatic cancers and most of other solid tumors [1]. The cisplatin anticancer efficacy is owing to its interaction with chromosomal DNA. phil\u0026teds smart buggy strollerWebA total of 26 patients with biopsy proved epidermoid carcinoma of the penis (Jackson stage III or IV) with measurable disease, no prior chemotherapy and adequate renal function … phil\u0026teds sport

"WebCisplatin (cis-diamminedichloroplatinum) is an alkylating agent and a subset of platinum (II) analogs. It acts by producing an immensely reactive moiety that facilitates the cross … " - Cisdiamminedichloroplatinum

Cisdiamminedichloroplatinum

WebJun 1, 1975 · Summary. The effects of cis -diamminedichloroplatinum (NSC 119875) on murine and human hemopoietic precursor cells were studied in culture. When murine … WebMar 1, 1979 · 1. Cisplatin is a co-ordination complex of a central platinum atom, two chlordies and two ammonia molecules in the “ cis ” position. 2. A prime mechanism of …

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WebWe demonstrated previously that the effect of cis-diamminedichloroplatinum(II) (cisplatin) against pancreatic cancer was substantially enhanced by the addition to the … WebCisplatin (cis-Diamminedichloroplatinum) is a organometallic compound and one of several platinum-based antineoplastic agents used in certain types of chemotherapy for the treatment of cancer. These compounds, …

WebA regression rate of 12% (4/33) among patients with advanced upper aerodigestive carcinomas who received an intravenous regimen of cis‐diamminedichloroplatinum, … WebA docetaxel-resistant prostate cell line (PC3DR2) was subsequently established using the same method (9); resistance-associated genes in this cell line were examined in the present study through DNA microarray, western blot analysis and reverse transcription-quantitative polymerase chain reaction (RT-qPCR).

WebThe thioredoxin (TRX) system, composed of nicotinamide adenine dinucleotide phosphate (reduced form), TRX, and TRX reductase (TRXR), has multiple biologic functions via thiol-mediated redox control. In this study, we investigated the relationship between intracellular TRXR levels and cellular sensitivity to cis-diamminedichloroplatinum (II) (CDDP). シスプラチン（英語: cisplatin、略称:CDDP）は、白金錯体に分類される抗悪性腫瘍剤（抗がん剤）。シスプラチンの「シス」は、立体化学の用語のシスに由来する。錯体の中心金属は白金、配位子はアンミンと塩化物イオンであり、物質名はシス-ジアミンジクロロ白金(II)（cis-diamminedichloro-platinum(II)、cis-[PtCl2(NH3)2]）である。なお、日光によって分解されるため、直射日光を避 …

WebCisplatin (cisplatinum, cis-diamminedichloroplatinum II, CDDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy. Solutions are best fresh-prepared. Catalog No. NC0564900 $86.10 / Each of 1 Qty Check Availability Add to cart

WebSpectrum of cis-diamminedichloroplatinum (II)-induced mutations in a shuttle vector propagated in human cells Spectrum of cis-diamminedichloroplatinum (II)-induced mutations in a shuttle vector propagated in human cells Authors G J Bubley 1 , B P Ashburner , B A Teicher Affiliation phil\u0026teds sport double kitWeba platinum coordination compound whose main mode of action resembles that of alkylating agents with production of cross links between the two strands of DNA in the double helix … phil \u0026 teds traveller cribWebCisplatin (cis-diamminedichloroplatinum II) Cisplatin (cis-diamminedichloroplatinum II) Cisplatin (cis-diamminedichloroplatinum II) Cancer Treat Rev. 1979 Mar;6(1):17-39. doi: … tsh slightly raisedWebA total of 26 patients with biopsy proved epidermoid carcinoma of the penis (Jackson stage III or IV) with measurable disease, no prior chemotherapy and adequate renal function received 50 mg. per M.2 cis-diamminedichloroplatinum intravenously on days 1 … tsh slightly elevated icd 10WebCis-diamminedichloroplatinum (II)-induced acute renal failure in the rat. Correlation of structural and functional alterations T. W. Jones, S. Chopra, J. S. Kaufman, W. … tsh slightly elevatedWebMay 15, 2015 · The interest in gold(III) as anticancer agent is a result of the current significance of the anticancer cisplatin, cis-diamminedichloroplatinum(II), [PtCl 2 (NH 3) 2] . Although cisplatin has been used for a long time for the treatment of different types of cancer there are several limitations and drawbacks. Gold(III) compounds provided ... tsh slightly highWebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, generating genetic and epigenetic changes that lead to the generation of resistance and the activation of intrinsic resistance mechanisms in cancer cells. Among them, we can find mutations, … tsh slot